Pyrophosphomevalonate decarboxylase

mevalonate (diphospho) decarboxylase
Identifiers
Symbol	MVD
Entrez	4597
HUGO	7529
OMIM	603236
RefSeq	NM_002461
UniProt	P53602
Other data
EC number	4.1.1.33
Locus	Chr. 16 q24.3

Pyrophosphomevalonate decarboxylase (or mevalonate-5-pyrophosphate decarboxylase) is an enzyme in the mevalonate pathway.

External links

MeSH Pyrophosphomevalonate+decarboxylase

Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Pyruvate decarboxylase · Oxaloacetate decarboxylase · Acetoacetate decarboxylase · Malonyl-CoA decarboxylase · Glutamate decarboxylase · Ornithine decarboxylase · Lysine decarboxylase · Phosphoribosylaminoimidazole carboxylase · Histidine decarboxylase · Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase · Aromatic L-amino acid decarboxylase · Phosphoenolpyruvate carboxylase · Pyrophosphomevalonate decarboxylase · Uroporphyrinogen III decarboxylase · RuBisCO · Phosphoenolpyruvate carboxykinase · Adenosylmethionine decarboxylase

4.1.2: Aldehyde-lyases	Aldolase (Aldolase A, Aldolase B, Aldolase C) · 2-hydroxyphytanoyl-CoA lyase · Threonine aldolase

4.1.3: Oxo-acid-lyases	3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other	Tryptophanase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase · Geranyl pyrophosphate

To lanosterol	Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase

Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase

Steroidogenesis

To pregnenolone

Side-chain cleavage

To corticosteroids

aldosterone: 18-hydroxylase

cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2)

both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase

To sex hormones

To androgens	17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase (1,2)

To estrogens	Aromatase

Other/ungrouped

Steroid metabolism: sulfatase (Steroid sulfatase) · sulfotransferase (SULT1A1, SULT2A1)

Steroidogenic acute regulatory protein

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)